Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
Postdoctoral clinical fellows Opportunities for postdoctoral clinicians to consolidate their research experience.
Breadcrumb Metabolomics Metabolomics : Publications Lab contentLab contentIn this section Overview Technologies Instrumentation Publications Members Publications Displaying 1 - 10 of 93Last updated : 24 April 2024 03:25 Metabolic priming by multiple enzyme systems supports glycolysis, HIF1α stabilisation, and human cancer cell survival in early hypoxia Authors (11)Fiona Grimm Agustín AsuajeAakriti JainMariana Silva Dos Santos Jens KleinjungPatricia Figueiredo Nunes Stefanie GehrigLouise Fets Salihanur DariciJames MacraeDimitrios Anastasiou The EMBO Journal Published 16 April 2024 Crick labs/ facilitiesDimitrios AnastasiouMetabolomicsBioinformatics and BiostatisticsLight MicroscopyHigh Throughput ScreeningAdvanced SequencingFull details microbeMASST: a taxonomically informed mass spectrometry search tool for microbial metabolomics data Authors (109) Simone Zuffa Robin Schmid Anelize Bauermeister Paulo Wender P Gomes Andres M Caraballo-Rodriguez Yasin El Abiead[...] Christopher M Rath Daniel McDonald Rob Knight Mingxun Wang Pieter C Dorrestein Nature Microbiology Published 1 February 2024 Crick labs/ facilitiesLuiz Pedro CarvalhoMetabolomicsFull details A palmitoyl transferase chemical-genetic system to map ZDHHC-specific S-acylation Authors (16) Cory A Ocasio Marc P Baggelaar James Sipthorp Ana Losada de la Lastra Manuel Tavares Jana Volarić[...]Goran TomicCharlotte CarrJulian Downward Ulrike S Eggert Edward W Tate Nature Biotechnology Published 8 January 2024 Crick labs/ facilitiesEd TateJulian DownwardMetabolomicsFlow CytometryChemical BiologyProteomicsLight MicroscopyCell ServicesAdvanced SequencingFull details Phenotypic profiling of solute carriers characterizes serine transport in cancer Authors (12)Vassilis Papalazarou Alice C Newman Alejandro Huerta-UribeNathalie Legrave Mattia Falcone Tong Zhang[...] Dimitris Athineos Emma Shanks Karen BlythKaren Vousden Oliver DK Maddocks Nature Metabolism Published 1 December 2023 Crick labs/ facilitiesKaren VousdenMetabolomicsLight MicroscopyHigh Throughput ScreeningFull details T cell migration requires ion and water influx to regulate actin polymerization Authors (13)Leon De BoerLesley Vanes Serena MelgratiJoshua Biggs O'MayDarryl HaywardPaul Driscoll[...] Renata Magueta Alexander MorrellJames MacraeRobert KoechlVictor Tybulewicz Nature Communications Published 6 December 2023 Crick labs/ facilitiesVictor TybulewiczMetabolomicsLight MicroscopyFlow CytometryBiological Research FacilityBioinformatics and BiostatisticsFull details Environmental chemicals change extracellular lipidome of mature human white adipocytes Authors (8) Paula BurkhardtSusana Palma-Duran Astrud RR Tuck Kalle Norgren Xinyi Li Violetta Nikiforova Julian L Griffin Vesna Munic Kos Chemosphere Published 1 February 2024 Crick labs/ facilitiesMetabolomicsFull details Vitamin B5 supports MYC oncogenic metabolism and tumor progression in breast cancer Authors (40) Peter Kreuzaler Paolo IngleseAvinash GhanateErsa Gjelaj Vincen WuYulia Panina[...] George Poulogiannis Greg McMahon Zoltan Takats Josephine BunchMariia Yuneva Nature Metabolism Published 1 November 2023 Crick labs/ facilitiesMariia YunevaLuiz Pedro CarvalhoMetabolomicsExperimental HistopathologyElectron MicroscopyBiological Research FacilityFull details Mechanism of substrate hydrolysis by the human nucleotide pool sanitiser DNPH1 Authors (8)Neil RzechorzekSimone Kunzelmann Andrew G PurkissMariana Silva Dos SantosJames MacraeIan TaylorKasper FuggerStephen West Nature Communications Published 26 October 2023 Crick labs/ facilitiesStephen WestIan TaylorStructural BiologyMetabolomicsFull details Peroxisomal compartmentalization of amino acid biosynthesis reactions imposes an upper limit on compartment size Authors (3)Ying GuSara AlamSnezhka Oliferenko Nature Communications Published 8 September 2023 Crick labs/ facilitiesSnezhana OliferenkoMetabolomicsFull details Loss of attachment promotes proline accumulation and excretion in cancer cells Authors (8)Steven PilleyMarc Hennequart Anke VandekeereJulianna BlagihNathalie Legrave Sarah-Maria FendtKaren Vousden Christiaan F Labuschagne Science advances Published 6 September 2023 Crick labs/ facilitiesKaren VousdenMetabolomicsFull details Pagination Current page 1 Page 2 Page 3 Page 4 Page 5 Page 6 Page 7 Page 8 Page 9 … Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Metabolic priming by multiple enzyme systems supports glycolysis, HIF1α stabilisation, and human cancer cell survival in early hypoxia Authors (11)Fiona Grimm Agustín AsuajeAakriti JainMariana Silva Dos Santos Jens KleinjungPatricia Figueiredo Nunes Stefanie GehrigLouise Fets Salihanur DariciJames MacraeDimitrios Anastasiou The EMBO Journal Published 16 April 2024 Crick labs/ facilitiesDimitrios AnastasiouMetabolomicsBioinformatics and BiostatisticsLight MicroscopyHigh Throughput ScreeningAdvanced SequencingFull details
microbeMASST: a taxonomically informed mass spectrometry search tool for microbial metabolomics data Authors (109) Simone Zuffa Robin Schmid Anelize Bauermeister Paulo Wender P Gomes Andres M Caraballo-Rodriguez Yasin El Abiead[...] Christopher M Rath Daniel McDonald Rob Knight Mingxun Wang Pieter C Dorrestein Nature Microbiology Published 1 February 2024 Crick labs/ facilitiesLuiz Pedro CarvalhoMetabolomicsFull details
A palmitoyl transferase chemical-genetic system to map ZDHHC-specific S-acylation Authors (16) Cory A Ocasio Marc P Baggelaar James Sipthorp Ana Losada de la Lastra Manuel Tavares Jana Volarić[...]Goran TomicCharlotte CarrJulian Downward Ulrike S Eggert Edward W Tate Nature Biotechnology Published 8 January 2024 Crick labs/ facilitiesEd TateJulian DownwardMetabolomicsFlow CytometryChemical BiologyProteomicsLight MicroscopyCell ServicesAdvanced SequencingFull details
Phenotypic profiling of solute carriers characterizes serine transport in cancer Authors (12)Vassilis Papalazarou Alice C Newman Alejandro Huerta-UribeNathalie Legrave Mattia Falcone Tong Zhang[...] Dimitris Athineos Emma Shanks Karen BlythKaren Vousden Oliver DK Maddocks Nature Metabolism Published 1 December 2023 Crick labs/ facilitiesKaren VousdenMetabolomicsLight MicroscopyHigh Throughput ScreeningFull details
T cell migration requires ion and water influx to regulate actin polymerization Authors (13)Leon De BoerLesley Vanes Serena MelgratiJoshua Biggs O'MayDarryl HaywardPaul Driscoll[...] Renata Magueta Alexander MorrellJames MacraeRobert KoechlVictor Tybulewicz Nature Communications Published 6 December 2023 Crick labs/ facilitiesVictor TybulewiczMetabolomicsLight MicroscopyFlow CytometryBiological Research FacilityBioinformatics and BiostatisticsFull details
Environmental chemicals change extracellular lipidome of mature human white adipocytes Authors (8) Paula BurkhardtSusana Palma-Duran Astrud RR Tuck Kalle Norgren Xinyi Li Violetta Nikiforova Julian L Griffin Vesna Munic Kos Chemosphere Published 1 February 2024 Crick labs/ facilitiesMetabolomicsFull details
Vitamin B5 supports MYC oncogenic metabolism and tumor progression in breast cancer Authors (40) Peter Kreuzaler Paolo IngleseAvinash GhanateErsa Gjelaj Vincen WuYulia Panina[...] George Poulogiannis Greg McMahon Zoltan Takats Josephine BunchMariia Yuneva Nature Metabolism Published 1 November 2023 Crick labs/ facilitiesMariia YunevaLuiz Pedro CarvalhoMetabolomicsExperimental HistopathologyElectron MicroscopyBiological Research FacilityFull details
Mechanism of substrate hydrolysis by the human nucleotide pool sanitiser DNPH1 Authors (8)Neil RzechorzekSimone Kunzelmann Andrew G PurkissMariana Silva Dos SantosJames MacraeIan TaylorKasper FuggerStephen West Nature Communications Published 26 October 2023 Crick labs/ facilitiesStephen WestIan TaylorStructural BiologyMetabolomicsFull details
Peroxisomal compartmentalization of amino acid biosynthesis reactions imposes an upper limit on compartment size Authors (3)Ying GuSara AlamSnezhka Oliferenko Nature Communications Published 8 September 2023 Crick labs/ facilitiesSnezhana OliferenkoMetabolomicsFull details
Loss of attachment promotes proline accumulation and excretion in cancer cells Authors (8)Steven PilleyMarc Hennequart Anke VandekeereJulianna BlagihNathalie Legrave Sarah-Maria FendtKaren Vousden Christiaan F Labuschagne Science advances Published 6 September 2023 Crick labs/ facilitiesKaren VousdenMetabolomicsFull details
