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Breadcrumb Metabolomics Metabolomics : Publications Lab contentLab contentIn this section Overview Technologies Instrumentation Publications Members Publications Displaying 21 - 30 of 93Last updated : 19 April 2024 03:17 The dietary sweetener sucralose is a negative modulator of T cell-mediated responses Authors (16)Fabio ZaniJulianna Blagih Tim GruberMichael Buck Nicholas JonesMarc Hennequart[...]Eric Cheung Ian S GilmoreAlex Gould Cristina Garcia-CaceresKaren Vousden Nature Published 23 March 2023 Crick labs/ facilitiesKaren VousdenCaetano Reis e SousaAlex GouldMetabolomicsBioinformatics and BiostatisticsLight MicroscopyFlow CytometryBiological Research FacilityAdvanced SequencingFull details Metabolic heterogeneity and cross-feeding within isogenic yeast populations captured by DILAC Authors (8)Stephan KamradClara Correia-Melo Lukasz SzyrwielSimran Aulakh Jürg BählerVadim Demichev Michael MüllederMarkus Ralser Nature Microbiology Published 1 March 2023 Crick labs/ facilitiesMarkus RalserMetabolomicsFull details Systematic diet composition swap in a mouse genome-scale metabolic model reveals determinants of obesogenic diet metabolism in liver cancer Authors (7) Frederick ClasenPatricia Figueiredo Nunes Gholamreza Bidkhori Nourdine BahStefan Boeing Saeed ShoaieDimitrios Anastasiou iScience Published 17 February 2023 Crick labs/ facilitiesDimitrios AnastasiouBioinformatics and BiostatisticsMetabolomicsIn Vivo ImagingBiological Research FacilityAdvanced SequencingFull details Cell-cell metabolite exchange creates a pro-survival metabolic environment that extends lifespan Authors (20)Clara Correia-MeloStephan Kamrad Roland TengölicsChristoph MessnerPauline TrebulleSt John Townsend[...]Vadim DemichevMichael Muelleder Balázs Papp Mohammad Tauqeer AlamMarkus Ralser Cell Published 5 January 2023 Crick labs/ facilitiesMarkus RalserMetabolomicsMedia PreparationFlow CytometryFull details A choline-releasing glycerophosphodiesterase essential for phosphatidylcholine biosynthesis and blood stage development in the malaria parasite Authors (11)Abhinay Ramaprasad Paul-Christian BurdaEnrica CalvaniAaron SaitSusana Palma-DuranChrislaine Withers-Martinez Fiona HackettJames MacraeLucy Collinson Tim Wolf GilbergerMichael Blackman eLife Published 28 December 2022 Crick labs/ facilitiesMike BlackmanMetabolomicsElectron MicroscopyLight MicroscopyFull details Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism Authors (17)Claudio Bussi Tiaan HeunisEnrica PellegrinoElliott Bernard Nourdine BahMariana Silva Dos Santos[...]James MacraeMaria Greco Thomas Reinheckel Matthias TrostMaximiliano Gutierrez Nature Communications Published 28 November 2022 Crick labs/ facilitiesMaximiliano GutierrezJulian DownwardMetabolomicsBioinformatics and BiostatisticsAdvanced SequencingLight MicroscopyHuman Embryonic Stem CellElectron MicroscopyAdvanced SequencingFull details N6-methyladenosine (m6A) reader Pho92 is recruited co-transcriptionally and couples translation to mRNA decay to promote meiotic fitness in yeast Authors (18) Radhika A VarierTheodora SideriCharlotte CapitanchikZornitsa ManovaEnrica CalvaniAlice Rossi[...] Michiel VermeulenMarkus RalserJernej UleNicholas LuscombeFolkert Van Werven eLife Published 24 November 2022 Crick labs/ facilitiesFolkert van WervenJernej UleMarkus RalserNicholas LuscombeProteomicsMetabolomicsBioinformatics and BiostatisticsFermentationAdvanced SequencingFull details Functional immune responses against SARS-CoV-2 variants of concern after fourth COVID-19 vaccine dose or infection in patients with blood cancer Authors (64)Annika FendlerScott ShepherdLewis AuMary Wu Ruth HarveyKatalin Wilkinson[...] Emma Nicholson Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic Cell Reports Medicine Published 18 October 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningScientific computingFull details MOG analogues to explore the MCT2 pharmacophore, α-ketoglutarate biology and cellular effects of N-oxalylglycine Authors (9)Louise FetsNatalie BevanPatricia Figueiredo Nunes Sebastien CamposMariana Silva Dos Santos Emma SherriffJames MacraeDavid HouseDimitrios Anastasiou Communications Biology Published 26 August 2022 Crick labs/ facilitiesDimitrios AnastasiouMetabolomicsTranslation teamFull details USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer Authors (19)Jessica Nelson May Zaw ThinTheo Evan Steven HowellMary WuBruna Almeida[...]Bram Snijders Andreas Prachalias Yoh Zen Debashis SarkerAxel Behrens Nature Communications Published 19 April 2022 Crick labs/ facilitiesPeter RatcliffeAxel BehrensProteomicsMetabolomicsHigh Throughput ScreeningExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingFull details Pagination First page First Previous page Previous Page 1 Page 2 Current page 3 Page 4 Page 5 Page 6 Page 7 Page 8 Page 9 … Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
The dietary sweetener sucralose is a negative modulator of T cell-mediated responses Authors (16)Fabio ZaniJulianna Blagih Tim GruberMichael Buck Nicholas JonesMarc Hennequart[...]Eric Cheung Ian S GilmoreAlex Gould Cristina Garcia-CaceresKaren Vousden Nature Published 23 March 2023 Crick labs/ facilitiesKaren VousdenCaetano Reis e SousaAlex GouldMetabolomicsBioinformatics and BiostatisticsLight MicroscopyFlow CytometryBiological Research FacilityAdvanced SequencingFull details
Metabolic heterogeneity and cross-feeding within isogenic yeast populations captured by DILAC Authors (8)Stephan KamradClara Correia-Melo Lukasz SzyrwielSimran Aulakh Jürg BählerVadim Demichev Michael MüllederMarkus Ralser Nature Microbiology Published 1 March 2023 Crick labs/ facilitiesMarkus RalserMetabolomicsFull details
Systematic diet composition swap in a mouse genome-scale metabolic model reveals determinants of obesogenic diet metabolism in liver cancer Authors (7) Frederick ClasenPatricia Figueiredo Nunes Gholamreza Bidkhori Nourdine BahStefan Boeing Saeed ShoaieDimitrios Anastasiou iScience Published 17 February 2023 Crick labs/ facilitiesDimitrios AnastasiouBioinformatics and BiostatisticsMetabolomicsIn Vivo ImagingBiological Research FacilityAdvanced SequencingFull details
Cell-cell metabolite exchange creates a pro-survival metabolic environment that extends lifespan Authors (20)Clara Correia-MeloStephan Kamrad Roland TengölicsChristoph MessnerPauline TrebulleSt John Townsend[...]Vadim DemichevMichael Muelleder Balázs Papp Mohammad Tauqeer AlamMarkus Ralser Cell Published 5 January 2023 Crick labs/ facilitiesMarkus RalserMetabolomicsMedia PreparationFlow CytometryFull details
A choline-releasing glycerophosphodiesterase essential for phosphatidylcholine biosynthesis and blood stage development in the malaria parasite Authors (11)Abhinay Ramaprasad Paul-Christian BurdaEnrica CalvaniAaron SaitSusana Palma-DuranChrislaine Withers-Martinez Fiona HackettJames MacraeLucy Collinson Tim Wolf GilbergerMichael Blackman eLife Published 28 December 2022 Crick labs/ facilitiesMike BlackmanMetabolomicsElectron MicroscopyLight MicroscopyFull details
Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism Authors (17)Claudio Bussi Tiaan HeunisEnrica PellegrinoElliott Bernard Nourdine BahMariana Silva Dos Santos[...]James MacraeMaria Greco Thomas Reinheckel Matthias TrostMaximiliano Gutierrez Nature Communications Published 28 November 2022 Crick labs/ facilitiesMaximiliano GutierrezJulian DownwardMetabolomicsBioinformatics and BiostatisticsAdvanced SequencingLight MicroscopyHuman Embryonic Stem CellElectron MicroscopyAdvanced SequencingFull details
N6-methyladenosine (m6A) reader Pho92 is recruited co-transcriptionally and couples translation to mRNA decay to promote meiotic fitness in yeast Authors (18) Radhika A VarierTheodora SideriCharlotte CapitanchikZornitsa ManovaEnrica CalvaniAlice Rossi[...] Michiel VermeulenMarkus RalserJernej UleNicholas LuscombeFolkert Van Werven eLife Published 24 November 2022 Crick labs/ facilitiesFolkert van WervenJernej UleMarkus RalserNicholas LuscombeProteomicsMetabolomicsBioinformatics and BiostatisticsFermentationAdvanced SequencingFull details
Functional immune responses against SARS-CoV-2 variants of concern after fourth COVID-19 vaccine dose or infection in patients with blood cancer Authors (64)Annika FendlerScott ShepherdLewis AuMary Wu Ruth HarveyKatalin Wilkinson[...] Emma Nicholson Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic Cell Reports Medicine Published 18 October 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningScientific computingFull details
MOG analogues to explore the MCT2 pharmacophore, α-ketoglutarate biology and cellular effects of N-oxalylglycine Authors (9)Louise FetsNatalie BevanPatricia Figueiredo Nunes Sebastien CamposMariana Silva Dos Santos Emma SherriffJames MacraeDavid HouseDimitrios Anastasiou Communications Biology Published 26 August 2022 Crick labs/ facilitiesDimitrios AnastasiouMetabolomicsTranslation teamFull details
USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer Authors (19)Jessica Nelson May Zaw ThinTheo Evan Steven HowellMary WuBruna Almeida[...]Bram Snijders Andreas Prachalias Yoh Zen Debashis SarkerAxel Behrens Nature Communications Published 19 April 2022 Crick labs/ facilitiesPeter RatcliffeAxel BehrensProteomicsMetabolomicsHigh Throughput ScreeningExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingFull details
