Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
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Breadcrumb Metabolomics Metabolomics : Publications Lab contentLab contentIn this section Overview Technologies Instrumentation Publications Members Publications Displaying 41 - 50 of 93Last updated : 16 April 2024 02:50 Extensive transcriptional and chromatin changes underlie astrocyte maturation in vivo and in culture Authors (9)Michael LattkeRobert GoldstoneJames EllisStefan Boeing Jerónimo Jurado-Arjona Nicolás MarichalJames Macrae Benedikt BerningerFrancois Guillemot Nature Communications Published 15 July 2021 Crick labs/ facilitiesFrancois GuillemotMetabolomicsBioinformatics and BiostatisticsAdvanced SequencingScientific computingBiological Research FacilityFull details E3 ubiquitin ligase HECTD2 mediates melanoma progression and immune evasion Authors (15)Eleonora OttinaVeera PanovaLaura DoglioAnastasiya Kazachenka Georgina CornishJoanna Kirkpatrick[...] Peter Van LooCharles SwantonJames Macrae Thomas TütingGeorge Kassiotis Oncogene Published 16 September 2021 Crick labs/ facilitiesPeter Van LooCharles SwantonJonathan StoyeGeorge KassiotisProteomicsMetabolomicsScientific computingLight MicroscopyFlow CytometryCell ServicesBiological Research FacilityFull details SARS-CoV-2 can recruit a haem metabolite to evade antibody immunity Authors (40)Annachiara RosaVal Pye Carl Graham Luke Muir Jeffrey SeowKevin Ng[...] Richard S TedderGeorge Kassiotis Laura E Mccoy Katie J DooresPeter Cherepanov Science advances Published 28 May 2021 Crick labs/ facilitiesPeter RosenthalGeorge KassiotisSteve GamblinPeter Cherepanov Rupert BealeStructural BiologyMetabolomicsFlow CytometryFull details Benefits of chemical sugar modifications introduced by click chemistry for glycoproteomic analyses Authors (11)Bea CalleGanka Bineva-ToddAndrea Marchesi Helen Flynn Mattia GhirardelloOmur Yilmaz TastanChloe Roustan Junwon Choi M Carmen GalanBen Schumann Stacy A Malaker Journal of the American Society for Mass Spectrometry Published 1 September 2021 Crick labs/ facilitiesBen SchumannStructural BiologyProteomicsMetabolomicsFull details Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors Authors (14)Kasper FuggerIlirjana BajramiMariana Silva Dos SantosSarah YoungSimone KunzelmannGeoff Kelly[...] Thomas CarellSimon BoultonJames MacraeIan TaylorStephen West Science Published 9 April 2021 Crick labs/ facilitiesStephen WestIan TaylorMRC Biomedical NMR CentreSimon BoultonStructural BiologyMRC Biomedical NMR CentreMetabolomicsBioinformatics and BiostatisticsAdvanced SequencingHigh Throughput ScreeningAdvanced SequencingFull details Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS-induced inflammation Authors (16) Nicholas JonesJulianna BlagihFabio Zani April Rees David G Hill Benjamin J Jenkins[...] Gareth W Jones David K FinlayKaren Vousden Emma E Vincent Catherine A Thornton Nature Communications Published 22 February 2021 Crick labs/ facilitiesKaren VousdenMetabolomicsFull details Single-cell resolved imaging reveals intra-tumor heterogeneity in glycolysis, transitions between metabolic states, and their regulatory mechanisms Authors (9)Hiroshi KondoColin RatcliffeSteven HooperJames EllisJames MacraeMarc Hennequart Christopher W DunsbyKurt AndersonErik Sahai Cell Reports Published 16 February 2021 Crick labs/ facilitiesKaren VousdenErik SahaiMetabolomicsLight MicroscopyFlow CytometryCell ServicesBiological Research FacilityFull details Repurposing the orphan drug nitisinone to control the transmission of African trypanosomiasis Authors (18) Marcos Sterkel Lee R Haines Aitor Casas-Sánchez Vincent Owino Adung'a Raquel J Vionette-Amaral Shannon Quek[...]James Macrae Daniel Masiga Laith Yakob Pedro L Oliveira Álvaro Acosta-Serrano PLOS Biology Published 26 January 2021 Crick labs/ facilitiesMetabolomicsFull details SARS-CoV-2 detection by a clinical diagnostic RT-LAMP assay Authors (40)Michael BuckEnzo PoirierAna Matos Cardoso Da SilvaBruno Frederico J CantonSam Barrell[...]Charles SwantonSamra TurajlicMary WuCaetano Reis e Sousa The Crick COVID-19 Consortium Wellcome Open Research Published 21 May 2021 Crick labs/ facilitiesSamra TurajlicCharles SwantonCaetano Reis e SousaGeorge KassiotisSonia GandhiRupert BealeMetabolomicsHigh Throughput ScreeningGenetic Modification ServiceBiological Research FacilityAdvanced SequencingStructural BiologyScientific computingFull details Rhythmic glucose metabolism regulates the redox circadian clockwork in human red blood cells Authors (12) Ratnasekhar Ch Guillaume Rey Sandipan Ray Pawan K JhaPaul DriscollMariana Silva Dos Santos[...] Radoslaw Lach Aalim M WeljieJames Macrae Utham K Valekunja Akhilesh B Reddy Nature Communications Published 15 January 2021 Crick labs/ facilitiesMetabolomicsMRC Biomedical NMR CentreFull details Pagination First page First Previous page Previous Page 1 Page 2 Page 3 Page 4 Current page 5 Page 6 Page 7 Page 8 Page 9 … Next page Next Last page Last Share the page Share on 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Extensive transcriptional and chromatin changes underlie astrocyte maturation in vivo and in culture Authors (9)Michael LattkeRobert GoldstoneJames EllisStefan Boeing Jerónimo Jurado-Arjona Nicolás MarichalJames Macrae Benedikt BerningerFrancois Guillemot Nature Communications Published 15 July 2021 Crick labs/ facilitiesFrancois GuillemotMetabolomicsBioinformatics and BiostatisticsAdvanced SequencingScientific computingBiological Research FacilityFull details
E3 ubiquitin ligase HECTD2 mediates melanoma progression and immune evasion Authors (15)Eleonora OttinaVeera PanovaLaura DoglioAnastasiya Kazachenka Georgina CornishJoanna Kirkpatrick[...] Peter Van LooCharles SwantonJames Macrae Thomas TütingGeorge Kassiotis Oncogene Published 16 September 2021 Crick labs/ facilitiesPeter Van LooCharles SwantonJonathan StoyeGeorge KassiotisProteomicsMetabolomicsScientific computingLight MicroscopyFlow CytometryCell ServicesBiological Research FacilityFull details
SARS-CoV-2 can recruit a haem metabolite to evade antibody immunity Authors (40)Annachiara RosaVal Pye Carl Graham Luke Muir Jeffrey SeowKevin Ng[...] Richard S TedderGeorge Kassiotis Laura E Mccoy Katie J DooresPeter Cherepanov Science advances Published 28 May 2021 Crick labs/ facilitiesPeter RosenthalGeorge KassiotisSteve GamblinPeter Cherepanov Rupert BealeStructural BiologyMetabolomicsFlow CytometryFull details
Benefits of chemical sugar modifications introduced by click chemistry for glycoproteomic analyses Authors (11)Bea CalleGanka Bineva-ToddAndrea Marchesi Helen Flynn Mattia GhirardelloOmur Yilmaz TastanChloe Roustan Junwon Choi M Carmen GalanBen Schumann Stacy A Malaker Journal of the American Society for Mass Spectrometry Published 1 September 2021 Crick labs/ facilitiesBen SchumannStructural BiologyProteomicsMetabolomicsFull details
Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors Authors (14)Kasper FuggerIlirjana BajramiMariana Silva Dos SantosSarah YoungSimone KunzelmannGeoff Kelly[...] Thomas CarellSimon BoultonJames MacraeIan TaylorStephen West Science Published 9 April 2021 Crick labs/ facilitiesStephen WestIan TaylorMRC Biomedical NMR CentreSimon BoultonStructural BiologyMRC Biomedical NMR CentreMetabolomicsBioinformatics and BiostatisticsAdvanced SequencingHigh Throughput ScreeningAdvanced SequencingFull details
Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS-induced inflammation Authors (16) Nicholas JonesJulianna BlagihFabio Zani April Rees David G Hill Benjamin J Jenkins[...] Gareth W Jones David K FinlayKaren Vousden Emma E Vincent Catherine A Thornton Nature Communications Published 22 February 2021 Crick labs/ facilitiesKaren VousdenMetabolomicsFull details
Single-cell resolved imaging reveals intra-tumor heterogeneity in glycolysis, transitions between metabolic states, and their regulatory mechanisms Authors (9)Hiroshi KondoColin RatcliffeSteven HooperJames EllisJames MacraeMarc Hennequart Christopher W DunsbyKurt AndersonErik Sahai Cell Reports Published 16 February 2021 Crick labs/ facilitiesKaren VousdenErik SahaiMetabolomicsLight MicroscopyFlow CytometryCell ServicesBiological Research FacilityFull details
Repurposing the orphan drug nitisinone to control the transmission of African trypanosomiasis Authors (18) Marcos Sterkel Lee R Haines Aitor Casas-Sánchez Vincent Owino Adung'a Raquel J Vionette-Amaral Shannon Quek[...]James Macrae Daniel Masiga Laith Yakob Pedro L Oliveira Álvaro Acosta-Serrano PLOS Biology Published 26 January 2021 Crick labs/ facilitiesMetabolomicsFull details
SARS-CoV-2 detection by a clinical diagnostic RT-LAMP assay Authors (40)Michael BuckEnzo PoirierAna Matos Cardoso Da SilvaBruno Frederico J CantonSam Barrell[...]Charles SwantonSamra TurajlicMary WuCaetano Reis e Sousa The Crick COVID-19 Consortium Wellcome Open Research Published 21 May 2021 Crick labs/ facilitiesSamra TurajlicCharles SwantonCaetano Reis e SousaGeorge KassiotisSonia GandhiRupert BealeMetabolomicsHigh Throughput ScreeningGenetic Modification ServiceBiological Research FacilityAdvanced SequencingStructural BiologyScientific computingFull details
Rhythmic glucose metabolism regulates the redox circadian clockwork in human red blood cells Authors (12) Ratnasekhar Ch Guillaume Rey Sandipan Ray Pawan K JhaPaul DriscollMariana Silva Dos Santos[...] Radoslaw Lach Aalim M WeljieJames Macrae Utham K Valekunja Akhilesh B Reddy Nature Communications Published 15 January 2021 Crick labs/ facilitiesMetabolomicsMRC Biomedical NMR CentreFull details
