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Close-up of X-ray crystallography equipment. Toggle to view hero caption Structural Biology : Publications Lab MenuLab Menu Overview Publications Members Breadcrumb Home Research Platforms & facilities Structural Biology Publications Publications Displaying 1 - 10 of 191Last updated : 05 August 2020 03:54 Cryo-EM of human Arp2/3 complexes provides structural insights into actin nucleation modulation by ARPC5 isoforms Authors (8) Ottilie von Loeffelholz Andrew Purkiss Luyan CaoSvend KjaerNaoko Kogata Guillaume Romet-LemonneMichael Way Carolyn A Moores Biology Open Published 13 July 2020 Crick labs/ facilitiesMichael WayStructural BiologyFull details Modular microfluidics enables kinetic insight from time-resolved cryo-EM Authors (11)Erik Maeots Byungjin LeeAndrea Nans Seung-Geun JeongNasr EsfahaniShan Ding Daniel J Smith Chang-Soo Lee Sung Sik Lee Matthias PeterRadoslav Enchev Nature Communications Published 10 July 2020 Crick labs/ facilitiesRadoslav EnchevStructural BiologyLight MicroscopyMaking LabFull details Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan Lewer Gavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesLuiz Pedro CarvalhoMike BlackmanDominique BonnetPeter Cherepanov Steve GamblinMaximiliano GutierrezGeorge KassiotisPaul NurseAnne O’GarraVenizelos PapayannopoulosLucia Prieto-GodinoPeter RatcliffeCaetano Reis e SousaErik SahaiCharles SwantonMoritz TreeckJames TurnerJernej UleKaren VousdenAndreas WackSonia GandhiRupert BealeAdam SaterialeAdvanced SequencingCell ServicesBioinformatics and BiostatisticsElectron MicroscopyExperimental HistopathologyFlow CytometryGenomics/Equipment ParkHigh Throughput ScreeningMetabolomicsPeptide ChemistryStructural BiologyFermentationWorldwide Influenza CentreHuman Embryonic Stem CellScientific computingFull details SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects Authors (8)Antoni WrobelDonald Benton Pengqi XuChloe Roustan Stephen R MartinPeter Rosenthal John J SkehelSteve Gamblin Nature Structural & Molecular Biology Published 9 July 2020 Crick labs/ facilitiesSteve GamblinPeter RosenthalStructural BiologyScientific computingFull details Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis Authors (7)Liz MorrisSarah CaswellSimone Kunzelmann Laurence H Arnold Andrew G PurkissGeoff KellyIan Taylor Nature Communications Published 23 June 2020 Crick labs/ facilitiesIan TaylorStructural BiologyMRC Biomedical NMR CentreFull details The ASC-1 complex disassembles collided ribosomes Authors (5) Szymon JuszkiewiczShaun SpeldewindeLi WanJesper Svejstrup Ramanujan S Hegde Molecular Cell Published 23 June 2020 Crick labs/ facilitiesJesper SvejstrupStructural BiologyFull details Ubiquitin activation is essential for schizont maturation in Plasmodium falciparum blood-stage development Authors (21)Judith Green Yang Wu Vesela Encheva Edwin Lasonder Adchara PrommabanSimone Kunzelmann[...] Gordon Langsley Hermann Schindelin Benjamin StieglitzBram SnijdersTony Holder PLOS Pathogens Published 22 June 2020 Crick labs/ facilitiesTony HolderProteomicsStructural BiologyTranslation teamFull details Scalable and robust SARS-CoV-2 testing in an academic center Authors (81) The Crick COVID-19 Consortium Jim Aitken Karen AmbroseSam BarrellRupert BealeGanka Bineva-Todd[...]Philip WalkerSophia Ward Wai Keong WongJoshua WrightMary Wu Nature Biotechnology Published 18 June 2020 Crick labs/ facilitiesPeter Cherepanov Steve GamblinGeorge KassiotisVenizelos PapayannopoulosPeter RatcliffeCaetano Reis e SousaCharles SwantonJames TurnerAndreas WackSonia GandhiRupert BealeAdvanced SequencingGenomics/Equipment ParkHigh Throughput ScreeningMetabolomicsPeptide ChemistryStructural BiologyFermentationScientific computingFull details Evidence that STK19 is not an NRAS-dependent melanoma driver Authors (11) Marta Rodríguez-Martínez Thierry Boissiére Melvin Noe GonzalezKevin Litchfield Richard MitterJane Walker Svend KjœrSoly IsmailJulian DownwardCharles SwantonJesper Svejstrup Cell Published 11 June 2020 Crick labs/ facilitiesJulian DownwardJesper SvejstrupCharles SwantonBioinformatics and BiostatisticsStructural BiologyCell ServicesProteomicsFull details Structural basis for the activation and target site specificity of CDC7 kinase Authors (6) Samual D DickStefania Federico Siobhan M HughesValerie PyeNicola O'ReillyPeter Cherepanov Structure Published 9 June 2020 Crick labs/ facilitiesPeter Cherepanov Peptide ChemistryStructural BiologyFull details Pagination Current page 1 Page 2 Page 3 Page 4 Page 5 Page 6 Page 7 Page 8 Page 9 … Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Cryo-EM of human Arp2/3 complexes provides structural insights into actin nucleation modulation by ARPC5 isoforms Authors (8) Ottilie von Loeffelholz Andrew Purkiss Luyan CaoSvend KjaerNaoko Kogata Guillaume Romet-LemonneMichael Way Carolyn A Moores Biology Open Published 13 July 2020 Crick labs/ facilitiesMichael WayStructural BiologyFull details
Modular microfluidics enables kinetic insight from time-resolved cryo-EM Authors (11)Erik Maeots Byungjin LeeAndrea Nans Seung-Geun JeongNasr EsfahaniShan Ding Daniel J Smith Chang-Soo Lee Sung Sik Lee Matthias PeterRadoslav Enchev Nature Communications Published 10 July 2020 Crick labs/ facilitiesRadoslav EnchevStructural BiologyLight MicroscopyMaking LabFull details
Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan Lewer Gavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesLuiz Pedro CarvalhoMike BlackmanDominique BonnetPeter Cherepanov Steve GamblinMaximiliano GutierrezGeorge KassiotisPaul NurseAnne O’GarraVenizelos PapayannopoulosLucia Prieto-GodinoPeter RatcliffeCaetano Reis e SousaErik SahaiCharles SwantonMoritz TreeckJames TurnerJernej UleKaren VousdenAndreas WackSonia GandhiRupert BealeAdam SaterialeAdvanced SequencingCell ServicesBioinformatics and BiostatisticsElectron MicroscopyExperimental HistopathologyFlow CytometryGenomics/Equipment ParkHigh Throughput ScreeningMetabolomicsPeptide ChemistryStructural BiologyFermentationWorldwide Influenza CentreHuman Embryonic Stem CellScientific computingFull details
SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects Authors (8)Antoni WrobelDonald Benton Pengqi XuChloe Roustan Stephen R MartinPeter Rosenthal John J SkehelSteve Gamblin Nature Structural & Molecular Biology Published 9 July 2020 Crick labs/ facilitiesSteve GamblinPeter RosenthalStructural BiologyScientific computingFull details
Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis Authors (7)Liz MorrisSarah CaswellSimone Kunzelmann Laurence H Arnold Andrew G PurkissGeoff KellyIan Taylor Nature Communications Published 23 June 2020 Crick labs/ facilitiesIan TaylorStructural BiologyMRC Biomedical NMR CentreFull details
The ASC-1 complex disassembles collided ribosomes Authors (5) Szymon JuszkiewiczShaun SpeldewindeLi WanJesper Svejstrup Ramanujan S Hegde Molecular Cell Published 23 June 2020 Crick labs/ facilitiesJesper SvejstrupStructural BiologyFull details
Ubiquitin activation is essential for schizont maturation in Plasmodium falciparum blood-stage development Authors (21)Judith Green Yang Wu Vesela Encheva Edwin Lasonder Adchara PrommabanSimone Kunzelmann[...] Gordon Langsley Hermann Schindelin Benjamin StieglitzBram SnijdersTony Holder PLOS Pathogens Published 22 June 2020 Crick labs/ facilitiesTony HolderProteomicsStructural BiologyTranslation teamFull details
Scalable and robust SARS-CoV-2 testing in an academic center Authors (81) The Crick COVID-19 Consortium Jim Aitken Karen AmbroseSam BarrellRupert BealeGanka Bineva-Todd[...]Philip WalkerSophia Ward Wai Keong WongJoshua WrightMary Wu Nature Biotechnology Published 18 June 2020 Crick labs/ facilitiesPeter Cherepanov Steve GamblinGeorge KassiotisVenizelos PapayannopoulosPeter RatcliffeCaetano Reis e SousaCharles SwantonJames TurnerAndreas WackSonia GandhiRupert BealeAdvanced SequencingGenomics/Equipment ParkHigh Throughput ScreeningMetabolomicsPeptide ChemistryStructural BiologyFermentationScientific computingFull details
Evidence that STK19 is not an NRAS-dependent melanoma driver Authors (11) Marta Rodríguez-Martínez Thierry Boissiére Melvin Noe GonzalezKevin Litchfield Richard MitterJane Walker Svend KjœrSoly IsmailJulian DownwardCharles SwantonJesper Svejstrup Cell Published 11 June 2020 Crick labs/ facilitiesJulian DownwardJesper SvejstrupCharles SwantonBioinformatics and BiostatisticsStructural BiologyCell ServicesProteomicsFull details
Structural basis for the activation and target site specificity of CDC7 kinase Authors (6) Samual D DickStefania Federico Siobhan M HughesValerie PyeNicola O'ReillyPeter Cherepanov Structure Published 9 June 2020 Crick labs/ facilitiesPeter Cherepanov Peptide ChemistryStructural BiologyFull details
