A call to action for deciphering genetic variants in human pluripotent stem cells for cell therapy

Authors list

Nissim Benvenisty Jonathan S Draper Paul J Gokhale Lyn Healy Zoe Hewitt Deborah Hursh Adam Hodgson Tenneille E Ludwig Nancy Mah Sarah E McClelland Milena Mennecozzi Florian T Merkle Joanne C Mountford Martin Pera Alessandro Prigione Tristan A Rodriguez Andrea Rossi Foad Rouhani Kourosh Saeb-Parsy Lucia Selfa Aspiroz Nika Shakiba Claudia Spits Peter D Tonge Ivana Barbaric
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Abstract

Human pluripotent stem cell (hPSC)-based therapies offer promise but pose potential risks due to culture-acquired genetic variants, some of which have been linked with cancer. An international workshop addressed these concerns, highlighting the need for improved strategies to stratify variants and chart a path toward definitive guidelines in hPSC-based therapy.

Journal details

Journal Cell Stem Cell
Volume 32
Issue number 4
Pages 508-512
Available online
Publication date

Full text links

Publisher website (DOI) 10.1016/j.stem.2025.03.003
Europe PubMed Central 40185071
Pubmed 40185071

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