A class I PI3K signalling network regulates primary cilia disassembly in normal physiology and disease
More about Open Access at the CrickAuthors list
Sarah E Conduit Wayne Pearce Amandeep Bhamra Benoit Bilanges Laura Bozal-Basterra Lazaros C Foukas Mathias Cobbaut Sandra D Castillo Mohammad Amin Danesh Mahreen Adil Arkaitz Carracedo Mariona Graupera Neil McDonald Peter Parker Pedro R Cutillas Silvia Surinova Bart VanhaesebroeckAbstract
Primary cilia are antenna-like organelles which sense extracellular cues and act as signalling hubs. Cilia dysfunction causes a heterogeneous group of disorders known as ciliopathy syndromes affecting most organs. Cilia disassembly, the process by which cells lose their cilium, is poorly understood but frequently observed in disease and upon cell transformation. Here, we uncover a role for the PI3Kα signalling enzyme in cilia disassembly. Genetic PI3Kα-hyperactivation, as observed in PIK3CA-related overgrowth spectrum (PROS) and cancer, induced a ciliopathy-like phenotype during mouse development. Mechanistically, PI3Kα and PI3Kβ produce the PIP3 lipid at the cilia transition zone upon disassembly stimulation. PI3Kα activation initiates cilia disassembly through a kinase signalling axis via the PDK1/PKCι kinases, the CEP170 centrosomal protein and the KIF2A microtubule-depolymerising kinesin. Our data suggest diseases caused by PI3Kα-activation may be considered 'Disorders with Ciliary Contributions', a recently-defined subset of ciliopathies in which some, but not all, of the clinical manifestations result from cilia dysfunction.
Journal details
Journal
Nature Communications
Volume
15
Issue number
1
Pages
7181
Available online
Publication date
Full text links
Publisher website (DOI)
10.1038/s41467-024-51354-1
Europe PubMed Central
39168978
Pubmed
39168978
Keywords
Related topics
Type of publication
