A comparative analysis of the foamy and ortho virus capsid structures reveals an ancient domain duplication
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The Spumaretrovirinae (foamy viruses) and the Orthoretrovirinae (e.g. HIV) share many similarities both in genome structure and the sequences of the core viral encoded proteins, such as the aspartyl protease and reverse transcriptase. Similarity in the gag region of the genome is less obvious at the sequence level but has been illuminated by the recent solution of the foamy virus capsid (CA) structure. This revealed a clear structural similarity to the orthoretrovirus capsids but with marked differences that left uncertainty in the relationship between the two domains that comprise the structure.
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Journal BMC Structural Biology
Volume 17
Issue number 1
Pages 3
Available online
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Publisher website (DOI) 10.1186/s12900-017-0073-0
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Europe PubMed Central 28372592
Pubmed 28372592
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