A comprehensive evaluation of rodent malaria parasite genomes and gene expression

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Authors list

Thomas D Otto Ulrike Böhme Andrew P Jackson Martin Hunt Blandine Franke-Fayard Wieteke AM Hoeijmakers Agnieszka A Religa Lauren Robertson Mandy Sanders Solabomi Ogun Deirdre Cunningham Annette Erhart Oliver Billker Shahid M Khan Hendrik G Stunnenberg Jean Langhorne Anthony Holder Andrew P Waters Chris I Newbold Arnab Pain Matthew Berriman Chris J Janse
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Abstract

Rodent malaria parasites (RMP) are used extensively as models of human malaria. Draft RMP genomes have been published for Plasmodium yoelii, P. berghei ANKA (PbA) and P. chabaudi AS (PcAS). Although availability of these genomes made a significant impact on recent malaria research, these genomes were highly fragmented and were annotated with little manual curation. The fragmented nature of the genomes has hampered genome wide analysis of Plasmodium gene regulation and function.

Journal details

Journal BMC Biology
Volume 12
Issue number 1
Pages 86
Publication date

Full text links

Publisher website (DOI) 10.1186/preaccept-1233682211145405
Europe PubMed Central 25359557
Pubmed 25359557

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Crick labs/facilities

Crick authors

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