A comprehensive survey of the mutagenic impact of common cancer cytotoxicsMore about Open Access at the Crick
Authors listBernadett Szikriszt Ádám Póti Orsolya Pipek Marcin Krzystanek Nnennaya Kanu János Molnár Dezső Ribli Zoltán Szeltner Gábor E Tusnády István Csabai Zoltan Szallasi Charles Swanton Dávid Szüts
Genomic mutations caused by cytotoxic agents used in cancer chemotherapy may cause secondary malignancies as well as contribute to the evolution of treatment-resistant tumour cells. The stable diploid genome of the chicken DT40 lymphoblast cell line, an established DNA repair model system, is well suited to accurately assay genomic mutations.
Journal Genome Biology
Issue number 1