A comprehensive survey of the mutagenic impact of common cancer cytotoxics

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Bernadett Szikriszt Ádám Póti Orsolya Pipek Marcin Krzystanek Nnennaya Kanu János Molnár Dezső Ribli Zoltán Szeltner Gábor E Tusnády István Csabai Zoltan Szallasi Charles Swanton Dávid Szüts
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Abstract

Genomic mutations caused by cytotoxic agents used in cancer chemotherapy may cause secondary malignancies as well as contribute to the evolution of treatment-resistant tumour cells. The stable diploid genome of the chicken DT40 lymphoblast cell line, an established DNA repair model system, is well suited to accurately assay genomic mutations.

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Journal Genome Biology
Volume 17
Issue number 1
Pages 99-99
Available online
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Publisher website (DOI) 10.1186/s13059-016-0963-7
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Europe PubMed Central 27161042
Pubmed 27161042

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