A different twist on centromeric chromatin
Abstract
Nucleosomes at the centromere contain CENP-A, a histone H3 variant that establishes a specific, yet poorly defined centromeric chromatin architecture. In this issue of Structure, Takizawa et al. (2019) describe an untwisted configuration for an H3-CENP-A-H3 tri-nucleosome that mimics centromeric chromatin. Untwisting may increase centromeric-protein accessibility to CENP-A in compacted chromatin.
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Publisher website (DOI) 10.1016/j.str.2019.12.005
Europe PubMed Central 31951537
Pubmed 31951537
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