A framework for advancing our understanding of cancer-associated fibroblastsMore about Open Access at the Crick
Authors listErik Sahai Igor Astsaturov Edna Cukierman David G DeNardo Mikala Egeblad Ronald M Evans Douglas Fearon Florian R Greten Sunil R Hingorani Tony Hunter Richard O Hynes Rakesh K Jain Tobias Janowitz Claus Jorgensen Alec C Kimmelman Mikhail G Kolonin Robert G Maki R Scott Powers Ellen Puré Daniel C Ramirez Ruth Scherz-Shouval Mara H Sherman Sheila Stewart Thea D Tlsty David A Tuveson Fiona M Watt Valerie Weaver Ashani T Weeraratna Zena Werb
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Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment with diverse functions, including matrix deposition and remodelling, extensive reciprocal signalling interactions with cancer cells and crosstalk with infiltrating leukocytes. As such, they are a potential target for optimizing therapeutic strategies against cancer. However, many challenges are present in ongoing attempts to modulate CAFs for therapeutic benefit. These include limitations in our understanding of the origin of CAFs and heterogeneity in CAF function, with it being desirable to retain some antitumorigenic functions. On the basis of a meeting of experts in the field of CAF biology, we summarize in this Consensus Statement our current knowledge and present a framework for advancing our understanding of this critical cell type within the tumour microenvironment.
Journal Nature Reviews Cancer
Issue number 3