A glucuronoxylomannan-associated immune signature, characterized by monocyte deactivation and an increased interleukin 10 level, is a predictor of death in cryptococcal meningitis
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James E Scriven Lisa M Graham Charlotte Schutz Thomas J Scriba Katalin Wilkinson Robert Wilkinson David R Boulware Britta C Urban David G Lalloo Graeme MeintjesAbstract
Cryptococcal meningitis remains a significant cause of death among human immunodeficiency virus type 1 (HIV)-infected persons in Africa. We aimed to better understand the pathogenesis and identify immune correlates of mortality, particularly the role of monocyte activation.
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Journal Journal of Infectious Diseases
Volume 213
Issue number 11
Pages 1725-1734
Available online
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Publisher website (DOI) 10.1093/infdis/jiw007
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Europe PubMed Central 26768248
Pubmed 26768248
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