A pilot study of plasma metabolomic patterns from patients treated with ketamine for bipolar depression: evidence for a response-related difference in mitochondrial networks
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A Villaseñor A Ramamoorthy Mariana Silva Dos Santos MP Lorenzo G Laje C Zarate C Barbas IW WainerAbstract
(R,S)-ketamine produces rapid and significant antidepressant effects in approximately 65% of patients suffering from treatment-resistant bipolar depression (BD). The genetic, pharmacological and biochemical differences between ketamine responders and non-responders have not been identified. The purpose of this study was to employ a metabolomics approach, a global, non-targeted determination of endogenous metabolic patterns, to identify potential markers of ketamine response and non-response.
Journal details
Journal British Journal of Pharmacology
Volume 171
Issue number 8
Pages 2230-2242
Publication date
Full text links
Publisher website (DOI) 10.1111/bph.12494
Europe PubMed Central 24684390
Pubmed 24684390
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