A Researcher’s guide to rodent models of Down syndrome: Recent insights and translational perspectives

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Authors list

Mir A Raza Andrew Folz Daniella B Victorino Zhuo Xing Xu-Qiao Chen Xinxin Zuo Leah K Borden Marie-Claude Potier William Mobley Mara Dierssen Masaharu Hiratsuka Yasuhiro Kazuki Kristy Welshhans Michelle Maugham-Macan Antonella Tramutola Eitan Okun Roger Reeves Randall J Roper Y Eugene Yu Yann Hérault Victor Tybulewicz Elizabeth MC Fisher Aaron Sathyanesan
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Abstract

Rodent models of Down syndrome (DS) have been transformative in identifying basic mechanisms underlying the effects of Trisomy 21 at the molecular, cellular, physiological, and neurobehavioral levels.
Each model, with its unique genomic architecture, has advanced our understanding of the complex multisystem etiology of DS. The availability of multiple models necessitates the challenge of selecting appropriate models to address a particular scientific question, experimental design, and translational relevance. This primer guides the reader through the various rodent models of DS and the genomic and phenotypic effects they recapitulate. We also provide recommendations and strategies for using DS rodent models to enable effective and robust forward and reverse translational approaches.

Journal details

Journal STAR Protocols
Volume 7
Issue number 3
Pages 104717
Available online
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Publisher website (DOI) 10.1016/j.xpro.2026.104717
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Europe PubMed Central 42501327
Pubmed 42501327

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