A roadmap to transform lung cancer outcomes: Priorities in biology, therapeutic innovation, early detection, prevention and interception
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Monte M Winslow Mohamed A Ahmed Christine D Berg James RM Black Julian Downward Ramaswamy Govindan Roy S Herbst John V Heymach Elizabeth M Jaffee Norbert Kraut Miriam Merad Matthew Meyerson Tej Pandya Katerina Politi Arati V Rao Charles M Rudin Jean Charles Soria Yuning J Tang Kwok-Kin Wong Timothy A Yap Charles Swanton The AACR Lung Cancer Task ForceAbstract
Advances in targeted therapies, immunotherapy, and early detection have revolutionized lung cancer treatment and extended survival. Nonetheless, lung cancer remains highly fatal. Here, we identify knowledge gaps and propose critical areas of future research, aligning with the mission of the AACR Lung Cancer Task Force. We delineate research priorities, including advancing prevention initiatives, enhancing early detection strategies, developing novel treatments, and refining patient stratification. Addressing disparities and increasing efforts on relatively neglected lung cancer subtypes are also essential. Finally, international collaboration, centralized clinical trial databases, novel clinical trial designs, and artificial intelligence-driven analytics should accelerate precision medicine and aid in elucidating drug resistance mechanisms. Together, these efforts promise to improve patient outcomes.
Journal details
Journal
Cancer Discovery
Volume
16
Issue number
6
Pages
1055-1073
Available online
Publication date
Full text links
Publisher website (DOI)
10.1158/2159-8290.CD-25-2318
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Europe PubMed Central
42001483
Pubmed
42001483
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