A simple predictive enhancer syntax for hindbrain patterning is conserved in vertebrate genomesMore about Open Access at the Crick
Authors listJoseph Grice Boris Noyvert Laura Doglio Greg Elgar
Determining the function of regulatory elements is fundamental for our understanding of development, disease and evolution. However, the sequence features that mediate these functions are often unclear and the prediction of tissue-specific expression patterns from sequence alone is non-trivial. Previous functional studies have demonstrated a link between PBX-HOX and MEIS/PREP binding interactions and hindbrain enhancer activity, but the defining grammar of these sites, if any exists, has remained elusive.
Journal PLOS ONE
Issue number 7