A simple predictive enhancer syntax for hindbrain patterning is conserved in vertebrate genomes

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Determining the function of regulatory elements is fundamental for our understanding of development, disease and evolution. However, the sequence features that mediate these functions are often unclear and the prediction of tissue-specific expression patterns from sequence alone is non-trivial. Previous functional studies have demonstrated a link between PBX-HOX and MEIS/PREP binding interactions and hindbrain enhancer activity, but the defining grammar of these sites, if any exists, has remained elusive.

Journal details

Journal PLOS ONE
Volume 10
Issue number 7
Pages e0130413
Available online
Publication date

Crick labs/facilities

Crick authors

Crick First author
Crick Corresponding author