A strong B-cell response is part of the immune landscape in human high-grade serous ovarian metastasesMore about Open Access at the Crick
Authors listAnne Montfort Oliver Pearce Eleni Maniati Benjamin G Vincent Lisa Bixby Steffen Böhm Thomas Dowe Edmund H Wilkes Probir Chakravarty Richard Thompson Joanne Topping Pedro R Cutillas Michelle Lockley Jonathan S Serody Melania Capasso Frances R Balkwill
In high-grade serous ovarian cancer (HGSOC), higher densities of both B cells and the CD8 T-cell infiltrate were associated with a better prognosis. However, the precise role of B cells in the antitumor response remains unknown. As peritoneal metastases are often responsible for relapse, our aim was to characterize the role of B cells in the antitumor immune response in HGSOC metastases.
Journal Clinical cancer research
Issue number 1