A strong B-cell response is part of the immune landscape in human high-grade serous ovarian metastases

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Authors list

Anne Montfort Oliver Pearce Eleni Maniati Benjamin G Vincent Lisa Bixby Steffen Böhm Thomas Dowe Edmund H Wilkes Probir Chakravarty Richard Thompson Joanne Topping Pedro R Cutillas Michelle Lockley Jonathan S Serody Melania Capasso Frances R Balkwill

Abstract

In high-grade serous ovarian cancer (HGSOC), higher densities of both B cells and the CD8 T-cell infiltrate were associated with a better prognosis. However, the precise role of B cells in the antitumor response remains unknown. As peritoneal metastases are often responsible for relapse, our aim was to characterize the role of B cells in the antitumor immune response in HGSOC metastases.

Journal details

Journal Clinical cancer research
Volume 23
Issue number 1
Pages 250-262
Available online
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Publisher website (DOI) 10.1158/1078-0432.ccr-16-0081
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Europe PubMed Central 27354470
Pubmed 27354470

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