A systematic screen reveals new elements acting at the G2/M cell cycle control

Journal Article: Genome BiologyYear Published: (2012) Volume Number: 13, Article Number: R36


Navarro,Francisco J; Nurse,Paul

The major cell cycle control acting at the G2 to mitosis transition is triggered in all eukaryotes by cyclin-dependent kinases (CDKs). In the fission yeast Schizosaccharomyces pombe the activation of the G2/M CDK is regulated primarily by dephosphorylation of the conserved residue Tyr15 in response to the stress-nutritional response and cell geometry sensing pathways. To obtain a more complete view of the G2/M control we have screened systematically for gene deletions that advance cells prematurely into mitosis.