ABCB1 (MDR1) induction defines a common resistance mechanism in paclitaxel- and olaparib-resistant ovarian cancer cells

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Authors list

Aparajitha Vaidyanathan Lynne Sawers Anne-Louise Gannon Probir Chakravarty Alison L Scott Susan E Bray Michelle J Ferguson Gillian Smith

Abstract

Clinical response to chemotherapy for ovarian cancer is frequently compromised by the development of drug-resistant disease. The underlying molecular mechanisms and implications for prescription of routinely prescribed chemotherapy drugs are poorly understood.

Journal details

Journal British Journal of Cancer
Volume 115
Issue number 4
Pages 431-441
Available online
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Publisher website (DOI) 10.1038/bjc.2016.203
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Europe PubMed Central 27415012
Pubmed 27415012

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