Acute immune signatures and their legacies in severe acute respiratory syndrome coronavirus-2 infected cancer patients
Authors listSultan Abdul-Jawad Luca Baù Thanussuyah Alaguthurai Irene Del Molino Del Barrio Adam G Laing Thomas S Hayday Leticia Monin Aldama Miguel Munoz-Ruiz Louisa McDonald Isaac Francos Quijorna Duncan McKenzie Richard Davis Anna Lorenc Julie Nuo En Chan Sarah Ryan Eva Bugallo-Blanco Rozalyn Yorke Shraddha Kamdar Matthew Fish Iva Zlatareva Pierre Vantourout Aislinn Jennings Sarah Gee Katie Doores Katharine Bailey Sophie Hazell Julien De Naurois Charlotte Moss Beth Russell Aadil A Khan Mark Rowley Reuben Benjamin Deborah Enting Doraid Alrifai Yin Wu You Zhou Paul Barber Tony Ng James Spicer Mieke Van Hemelrijck Mayur Kumar Jennifer Vidler Yadanar Lwin Paul Fields Sophia N Karagiannis Anthony CC Coolen Anne Rigg Sophie Papa Adrian Hayday Piers EM Patten Sheeba Irshad
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Given the immune system’s importance for cancer surveillance and treatment, we have investigated how it may be affected by SARS-CoV-2 infection of cancer patients. Across some heterogeneity in tumour type, stage and treatment, virus-exposed solid cancer patients display a dominant impact of SARS-CoV-2, apparent from the resemblance of their immune signatures to those for COVID-19+ non-cancer patients. This is not the case for haematological malignancies, with virus-exposed patients collectively displaying heterogeneous humoral responses, an exhausted T cell phenotype and a high prevalence of prolonged virus shedding. Furthermore, while recovered solid cancer patients’ immunophenotypes resemble those of non-virus-exposed cancer patients, recovered haematological cancer patients display distinct, lingering immunological legacies. Thus, while solid cancer patients, including those with advanced disease, seem no more at risk of SARS-CoV-2-associated immune dysregulation than the general population, haematological cancer patients show complex immunological consequences of SARS-CoV-2 exposure that might usefully inform their care.
Journal Cancer Cell
Issue number 2