Acylation-coupled lipophilic induction of polarisation (Acyl-cLIP): a universal assay for lipid transferase and hydrolase enzymes
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Thomas Lanyon-Hogg Markus Ritzefeld Lea Sefer Jasmine K Bickel Amalie F Rudolf Nattawadee Panyain Ganka Bineva-Todd Cory A Ocasio Nicola O'Reilly Christian Siebold Anthony I Magee Edward W TateAbstract
A highly accurate and versatile fluorescence polarisation assay for any enzyme adding or removing lipid posttranslational modifications, with the potential to accelerate drug discovery against these targets.
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Journal Chemical Science
Volume 10
Issue number 39
Pages 8995-9000
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Publisher website (DOI) 10.1039/c9sc01785b
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Europe PubMed Central 31762980
Pubmed 31762980
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