Adaptive from innate: Human IFN-γ+CD4+ T cells can arise directly from CXCL8-producing recent thymic emigrants in babies and adults
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Abhishek Das Kevin Rouault-Pierre Shraddha Kamdar Iria Gomez-Tourino Kristie Wood Ian Donaldson Charles A Mein Dominique Bonnet Adrian Hayday Deena L GibbonsAbstract
We recently demonstrated that the major effector function of neonatal CD4+ T cells is to produce CXCL8, a prototypic cytokine of innate immune cells. In this article, we show that CXCL8 expression, prior to proliferation, is common in newly arising T cells (so-called "recent thymic emigrants") in adults, as well as in babies. This effector potential is acquired in the human thymus, prior to TCR signaling, but rather than describing end-stage differentiation, such cells, whether isolated from neonates or adults, can further differentiate into IFN-γ-producing CD4+ T cells. Thus, the temporal transition of host defense from innate to adaptive immunity is unexpectedly mirrored at the cellular level by the capacity of human innate-like CXCL8-producing CD4+ T cells to transition directly into Th1 cells.
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Journal Journal of Immunology
Volume 199
Issue number 5
Pages 1696-1705
Available online
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Publisher website (DOI) 10.4049/jimmunol.1700551
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Europe PubMed Central 28754679
Pubmed 28754679
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