Alpha-synuclein oligomers interact with metal ions to induce oxidative stress and neuronal death in Parkinson's disease


Protein aggregation and oxidative stress are both key pathogenic processes in Parkinson's disease, although the mechanism by which misfolded proteins induce oxidative stress and neuronal death remains unknown. In this study, we describe how aggregation of alpha-synuclein (α-S) from its monomeric form to its soluble oligomeric state results in aberrant free radical production and neuronal toxicity.

Journal details

Volume 24
Issue number 7
Pages 376-391
Available online
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