Aminoglycoside binding and catalysis specificity of aminoglycoside 2''-phosphotransferase IVa: a thermodynamic, structural and kinetic study
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Elise Kaplan Jean-François Guichou Laurent Chaloin Simone Kunzelmann Nadia Leban Engin H Serpersu Corinne LionneAbstract
Aminoglycoside O-phosphotransferases make up a large class of bacterial enzymes that is widely distributed among pathogens and confer a high resistance to several clinically used aminoglycoside antibiotics. Aminoglycoside 2″-phosphotransferase IVa, APH(2″)-IVa, is an important member of this class, but there is little information on the thermodynamics of aminoglycoside binding and on the nature of its rate-limiting step.
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Journal Biochimica et Biophysica Acta
Volume 1860
Issue number 4
Pages 802-813
Available online
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Publisher website (DOI) 10.1016/j.bbagen.2016.01.016
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Europe PubMed Central 26802312
Pubmed 26802312
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