An improved method for the incorporation of fluoromethyl ketones into solid phase peptide synthesis techniquesMore about Open Access at the Crick
Authors listDhira Joshi Jennifer Milligan Theresa Zeisner Nicola O'Reilly John Diffley George Papageorgiou
An improved and expedient technique for the synthesis of peptidyl-fluoromethyl ketones is described. The methodology is based on prior coupling of an aspartate fluoromethyl ketone to a linker and mounting it onto resin-bound methylbenzhydrylamine hydrochloride. Subsequently, by utilising standard Fmoc peptide procedures, a number of short Z-protected peptides were synthesised and assessed as possible inhibitors of the main protease from SARS-CoV-2 (3CLpro).
Issue number 33