Analyzing Th17 cell differentiation dynamics using a novel integrative modeling framework for time-course RNA sequencing data

More about Open Access at the Crick


The differentiation of naive CD 4(+) helper T (Th) cells into effector Th17 cells is steered by extracellular cytokines that activate and control the lineage specific transcriptional program. While the inducing cytokine signals and core transcription factors driving the differentiation towards Th17 lineage are well known, detailed mechanistic interactions between the key components are poorly understood.

Journal details

Volume 9
Issue number 1
Pages 81
Available online
Publication date


Related topics

Crick labs/facilities