Ancient Pbx-Hox signatures define hundreds of vertebrate developmental enhancers


Gene regulation through cis-regulatory elements plays a crucial role in development and disease. A major aim of the post-genomic era is to be able to read the function of cis-regulatory elements through scrutiny of their DNA sequence. Whilst comparative genomics approaches have identified thousands of putative regulatory elements, our knowledge of their mechanism of action is poor and very little progress has been made in systematically de-coding them.

Journal details

Journal BMC Genomics
Volume 12
Issue number 1
Pages 637
Publication date


Crick labs/facilities