Annotation matters: validating the discovery of cancer drivers
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Advanced sequencing techniques have helped unveil numerous new, potential cancer driver mutations. However, manual curation and analysis of gene and protein annotation are essential to verify such discoveries. Our recent study of (Serine Threonine Kinase 19), a previously identified melanoma driver, is a clear example of the importance of such detailed analysis, with both STK19 gene and protein annotations in frequently used databases having been proven incorrect.
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Journal Molecular & Cellular Oncology
Volume 7
Issue number 6
Pages e1806679
Available online
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Publisher website (DOI) 10.1080/23723556.2020.1806679
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Europe PubMed Central 33235910
Pubmed 33235910
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