Annotation matters: validating the discovery of cancer driversMore about Open Access at the Crick
Authors listMarta Rodriguez Martinez Jesper Svejstrup
Advanced sequencing techniques have helped unveil numerous new, potential cancer driver mutations. However, manual curation and analysis of gene and protein annotation are essential to verify such discoveries. Our recent study of (Serine Threonine Kinase 19), a previously identified melanoma driver, is a clear example of the importance of such detailed analysis, with both STK19 gene and protein annotations in frequently used databases having been proven incorrect.
Journal Molecular & Cellular Oncology
Issue number 6