Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein

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Antoni Wrobel Donald Benton Saira Hussain Ruth Harvey Stephen R Martin Chloe Roustan Peter Rosenthal John J Skehel Steve Gamblin
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Abstract

The CR3022 antibody, selected from a group of SARS-CoV monoclonal antibodies for its ability to cross-react with SARS-CoV-2, has been examined for its ability to bind to the ectodomain of the SARS-CoV-2 spike glycoprotein. Using cryo-electron microscopy we show that antibody binding requires rearrangements in the S1 domain that result in dissociation of the spike.

Journal details

Journal Nature Communications
Volume 11
Issue number 1
Pages 5337
Available online
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Publisher website (DOI) 10.1038/s41467-020-19146-5
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Europe PubMed Central 33087721
Pubmed 33087721

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The publication was previously a preprint. View preprint