Antibody-mediated disruption of the SARS-CoV-2 spike glycoproteinMore about Open Access at the Crick
Authors listAntoni Wrobel Donald Benton Saira Hussain Ruth Harvey Stephen R Martin Chloe Roustan Peter Rosenthal John J Skehel Steve Gamblin
The CR3022 antibody, selected from a group of SARS-CoV monoclonal antibodies for its ability to cross-react with SARS-CoV-2, has been examined for its ability to bind to the ectodomain of the SARS-CoV-2 spike glycoprotein. Using cryo-electron microscopy we show that antibody binding requires rearrangements in the S1 domain that result in dissociation of the spike.
Journal Nature Communications
Issue number 1