APC moonlights to prevent wnt signalosome assembly

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The scaffold protein APC has a well-known function in ensuring β-catenin destruction. In this issue of Developmental Cell, Saito-Diaz et al. (2018) uncover another role for APC in Wnt signaling: to prevent clathrin-dependent signalosome formation in the absence of ligand.

Journal details

Volume 44
Issue number 5
Pages 535-537
Publication date