APOBEC3 as a driver of genetic intratumor heterogeneity

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Our recent study revealed that APOBEC3B is upregulated during the preinvasive stages of non-small cell lung cancer and breast cancer. In addition to its role in mediating single nucleotide variants, we propose that APOBEC3 promotes copy number intratumor heterogeneity prior to invasion, providing a substrate for cancer evolution.

Journal details

Volume 10
Issue number 1
Pages 2014734
Available online
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