APOBEC3 as a driver of genetic intratumor heterogeneity

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Mani Venkatesan Mihaela Angelova Jirina Bartkova Samuel F Bakhoum Jiri Bartek Nnennaya Kanu Charles Swanton
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Abstract

Our recent study revealed that APOBEC3B is upregulated during the preinvasive stages of non-small cell lung cancer and breast cancer. In addition to its role in mediating single nucleotide variants, we propose that APOBEC3 promotes copy number intratumor heterogeneity prior to invasion, providing a substrate for cancer evolution.

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Journal Molecular and Cellular Oncology
Volume 10
Issue number 1
Pages 2014734
Available online
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Publisher website (DOI) 10.1080/23723556.2021.2014734
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Europe PubMed Central 38116246
Pubmed 38116246

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