APOBEC3 as a driver of genetic intratumor heterogeneity

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Subramanian Venkatesan Mihaela Angelova J Bartkova SF Bakhoum J Bartek N Kanu Charles Swanton
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Abstract

Our recent study revealed that APOBEC3B is upregulated during the preinvasive stages of non-small cell lung cancer and breast cancer. In addition to its role in mediating single nucleotide variants, we propose that APOBEC3 promotes copy number intratumor heterogeneity prior to invasion, providing a substrate for cancer evolution.

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Journal Molecular and Cellular Oncology
Pages Epub ahead of print
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Publisher website (DOI) 10.1080/23723556.2021.2014734

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