Autophagy in major human diseases
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Daniel J Klionsky Giulia Petroni Ravi K Amaravadi Eric H Baehrecke Andrea Ballabio Patricia Boya José Manuel Bravo-San Pedro Ken Cadwell Francesco Cecconi Augustine MK Choi Mary E Choi Charleen T Chu Patrice Codogno Maria Isabel Colombo Ana Maria Cuervo Vojo Deretic Ivan Dikic Zvulun Elazar Eeva-Liisa Eskelinen Gian Maria Fimia David A Gewirtz Douglas R Green Malene Hansen Marja Jäättelä Terje Johansen Gábor Juhász Vassiliki Karantza Claudine Kraft Guido Kroemer Nicholas T Ktistakis Sharad Kumar Carlos Lopez-Otin Kay F Macleod Frank Madeo Jennifer Martinez Alicia Meléndez Noboru Mizushima Christian Münz Josef M Penninger Rushika M Perera Mauro Piacentini Fulvio Reggiori David C Rubinsztein Kevin M Ryan Junichi Sadoshima Laura Santambrogio Luca Scorrano Hans-Uwe Simon Anna Katharina Simon Anne Simonsen Alexandra Stolz Nektarios Tavernarakis Sharon Tooze Tamotsu Yoshimori Junying Yuan Zhenyu Yue Qing Zhong Lorenzo Galluzzi Federico Pietrocola Toggle all authors (59)
Abstract
Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.
Journal details
Journal The EMBO Journal
Volume 40
Issue number 19
Pages e108863
Available online
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Publisher website (DOI) 10.15252/embj.2021108863
Europe PubMed Central 34459017
Pubmed 34459017
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