Autophagy regulation through Atg9 traffic
Abstract
Rapid membrane expansion is the key to autophagosome formation during nutrient starvation. In this issue, Yamamoto et al. (2012. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201202061) now provide a mechanism for vesicle-mediated initiation of autophagosome biogenesis. They show that Atg9 vesicles, produced de novo during starvation, are ∼30-60 nm in size and contain ∼30 molecules of Atg9. These vesicles assemble to form an autophagosome, and subsequently, the Atg9 embedded in the outer membrane is recycled to avoid degradation.
Journal details
Journal Journal of Cell Biology
Volume 198
Issue number 2
Pages 151-153
Publication date
Full text links
Publisher website (DOI) 10.1083/jcb.201206119
Europe PubMed Central 22826119
Pubmed 22826119
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