Balancing cell behavior at boundaries
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David G WilkinsonAbstract
The restriction of cell intermingling across boundaries is essential for the establishment of discrete tissues. Eph receptor signaling prevents intermingling at many boundaries. In this issue, Luu et al. (2015. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201409026) report a parallel pathway, mediated by Wnt signaling, Snail1, and paraxial protocadherin (PAPC). This pathway establishes a distinctive organization of cell adhesion and intercellular gaps at the interface between tissues.
Journal details
Journal Journal of Cell Biology
Volume 208
Issue number 6
Pages 659-660
Publication date
Full text links
Publisher website (DOI) 10.1083/jcb.201501107
Europe PubMed Central 25778916
Pubmed 25778916
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