Beyond TGFβ: roles of other TGFβ superfamily members in cancer
Abstract
Much of the focus on the transforming growth factor-β (TGFβ) superfamily in cancer has revolved around the TGFβ ligands themselves. However, it is now becoming apparent that deregulated signalling by many of the other superfamily members also has crucial roles in both the development of tumours and metastasis. Furthermore, these signalling pathways are emerging as plausible therapeutic targets. Their roles in tumorigenesis frequently reflect their function in embryonic development or in adult tissue homeostasis, and their influence extends beyond the tumours themselves, to the tumour microenvironment and more widely to complications of cancer such as cachexia and bone loss.
Journal details
Journal Nature Reviews Cancer
Volume 13
Issue number 5
Pages 328-341
Publication date
Full text links
Publisher website (DOI) 10.1038/nrc3500
Europe PubMed Central 23612460
Pubmed 23612460
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