Biolayer interferometry: Protein-RNA interactions


RNA-binding proteins often contain multiple RNA-binding domains connected by short flexible linkers. This domain arrangement allows the protein to bind the RNA with greater affinity and specificity than would be possible with individual domains and sometimes to remodel its structure. It is therefore important to understand how multiple modules interact with RNA because it is the modular nature of these proteins which specifies their biological function. This chapter is concerned with the use of biolayer interferometry to study protein-RNA interactions.

Journal details

Volume 2263
Pages 351-368
Available online
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Crick labs/facilities

Crick authors

Crick First author
Crick Corresponding author