Building bridges between cellular and molecular structural biologyMore about Open Access at the Crick
Authors listArdan Patwardhan Robert Brandt Sarah J Butcher Lucy Collinson David Gault Kay Grünewald Corey Hecksel Juha T Huiskonen Andrii Iudin Martin Jones Paul K Korir Abraham J Koster Ingvar Lagerstedt Catherine L Lawson David Mastronarde Matthew McCormick Helen Parkinson Peter Rosenthal Stephan Saalfeld Helen R Saibil Sirarat Sarntivijai Irene Solanes Valero Sriram Subramaniam Jason R Swedlow Ilinca Tudose Martyn Winn Gerard J Kleywegt
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The integration of cellular and molecular structural data is key to understanding the function of macromolecular assemblies and complexes in their in vivo context. Here we report on the outcomes of a workshop that discussed how to integrate structural data from a range of public archives. The workshop identified two main priorities: the development of tools and file formats to support segmentation (that is, the decomposition of a three-dimensional volume into regions that can be associated with defined objects), and the development of tools to support the annotation of biological structures.