Butler enables rapid cloud-based analysis of thousands of human genomesMore about Open Access at the Crick
Authors listSergei Yakneen Sebastian M Waszak PCAWG Technical Working Group Michael Gertz Jan O Korbel PCAWG Consortium
We present Butler, a computational tool that facilitates large-scale genomic analyses on public and academic clouds. Butler includes innovative anomaly detection and self-healing functions that improve the efficiency of data processing and analysis by 43% compared with current approaches. Butler enabled processing of a 725-terabyte cancer genome dataset from the Pan-Cancer Analysis of Whole Genomes (PCAWG) project in a time-efficient and uniform manner.
Journal Nature Biotechnology
Issue number 3