Cell-cell metabolite exchange creates a pro-survival metabolic environment that extends lifespanMore about Open Access at the Crick
Authors listClara Correia-Melo Stephan Kamrad Roland Tengölics Christoph Messner Pauline Trebulle St John Townsend Sreejith Jayasree Varma Anja Freiwald Benjamin M Heineike Kate Campbell Lucia Herrera Dominguez Simran Aulakh Lukasz Szyrwiel Jason SL Yu Aleksej Zelezniak Vadim Demichev Michael Muelleder Balázs Papp Mohammad Tauqeer Alam Markus Ralser
Metabolism is deeply intertwined with aging. Effects of metabolic interventions on aging have been explained with intracellular metabolism, growth control, and signaling. Studying chronological aging in yeast, we reveal a so far overlooked metabolic property that influences aging via the exchange of metabolites. We observed that metabolites exported by young cells are re-imported by chronologically aging cells, resulting in cross-generational metabolic interactions. Then, we used self-establishing metabolically cooperating communities (SeMeCo) as a tool to increase metabolite exchange and observed significant lifespan extensions. The longevity of the SeMeCo was attributable to metabolic reconfigurations in methionine consumer cells. These obtained a more glycolytic metabolism and increased the export of protective metabolites that in turn extended the lifespan of cells that supplied them with methionine. Our results establish metabolite exchange interactions as a determinant of cellular aging and show that metabolically cooperating cells can shape the metabolic environment to extend their lifespan.
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