Cell division: Switching on ECT2 in a non-canonical fashion


Determining the site of cell cleavage is crucial for cytokinesis and involves precise activation of the RhoGEF ECT2. A new study demonstrates how a non-canonical interaction of ECT2 with centralspindlin underlies cytokinesis in animal cells, solving a mechanistic conundrum.

Journal details

Journal Current Biology
Volume 30
Issue number 16
Pages R947-R949
Available online
Publication date

Crick labs/facilities