Cell division: Switching on ECT2 in a non-canonical fashion
Abstract
Determining the site of cell cleavage is crucial for cytokinesis and involves precise activation of the RhoGEF ECT2. A new study demonstrates how a non-canonical interaction of ECT2 with centralspindlin underlies cytokinesis in animal cells, solving a mechanistic conundrum.
Journal details
Journal Current Biology
Volume 30
Issue number 16
Pages R947-R949
Available online
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Publisher website (DOI) 10.1016/j.cub.2020.06.073
Europe PubMed Central 32810457
Pubmed 32810457
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