Challenging the "chromatin hypothesis" of cardiac laminopathies with LMNA mutant iPS cells
Abstract
Lamins A and C are intermediate filaments that provide structural support to the nuclear envelope and regulate gene expression. In this issue, Bertero et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201902117) report that although lamin A/C haploinsufficient cardiomyocytes show disease-associated phenotypes, those changes cannot be explained by alterations in chromatin compartmentalization.
Journal details
Journal The Journal of Cell Biology
Volume 218
Issue number 9
Pages 2826-2828
Available online
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Publisher website (DOI) 10.1083/jcb.201907166
Europe PubMed Central 31427369
Pubmed 31427369
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