Cis-regulatory control of human GLI2 expression in the developing neural tube and limb bud
Authors listRashid Minhas Stefan Pauls Shahid Ali Laura Doglio Muhammad Ramzan Khan Greg Elgar Amir Ali Abbasi
GLI2, a zinc finger transcription factor, mediates Sonic hedgehog signaling, a critical pathway in vertebrate embryogenesis. GLI2 has been implicated in diverse set of embryonic developmental processes, including patterning of central nervous system and limbs. In humans, mutations in GLI2 are associated with several developmental defects, including holoprosencephaly and polydactyly.