Cis-regulatory control of human GLI2 expression in the developing neural tube and limb bud


GLI2, a zinc finger transcription factor, mediates Sonic hedgehog signaling, a critical pathway in vertebrate embryogenesis. GLI2 has been implicated in diverse set of embryonic developmental processes, including patterning of central nervous system and limbs. In humans, mutations in GLI2 are associated with several developmental defects, including holoprosencephaly and polydactyly.

Journal details

Volume 244
Issue number 5
Pages 681-692
Publication date


Crick labs/facilities