Cis-regulatory control of human GLI2 expression in the developing neural tube and limb bud
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Rashid Minhas Stefan Pauls Shahid Ali Laura Doglio Muhammad Ramzan Khan Greg Elgar Amir Ali AbbasiAbstract
GLI2, a zinc finger transcription factor, mediates Sonic hedgehog signaling, a critical pathway in vertebrate embryogenesis. GLI2 has been implicated in diverse set of embryonic developmental processes, including patterning of central nervous system and limbs. In humans, mutations in GLI2 are associated with several developmental defects, including holoprosencephaly and polydactyly.
Journal details
Journal Developmental Dynamics
Volume 244
Issue number 5
Pages 681-692
Publication date
Full text links
Publisher website (DOI) 10.1002/dvdy.24266
Europe PubMed Central 25715918
Pubmed 25715918
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