Clone competition as a mechanism to reduce tumor formation
Authors listAmelia Acha Ilaria Malanchi Francesca Ciccarelli
With age, clones carrying somatic mutations in well-known cancer driver genes progressively populate adult tissues, yet cancer transformation is rare. In a recent issue of Nature, Colom et al. showed that competition between mutated clones with different fitness could act as a tumor-protective mechanism.
Journal Developmental Cell
Issue number 24