Co-infection with Mycobacterium tuberculosis and human immunodeficiency virus: an overview and motivation for systems approaches
Abstract
Tuberculosis is a devastating disease that accounts for a high proportion of infectious disease morbidity and mortality worldwide. HIV-1 co-infection exacerbates tuberculosis. Enhanced understanding of the host-pathogen relationship in HIV-1 and Mycobacterium tuberculosis co-infection is required. While reductionist approaches have yielded many valuable insights into disease pathogenesis, systems approaches are required that develop data-driven models able to predict emergent properties of this complex co-infection system in order to develop novel therapeutic approaches and to improve diagnostics. Here, we provide a pathogenesis-focused overview of HIV-TB co-infection followed by an introduction to systems approaches and concrete examples of how such approaches are useful.
Journal details
Journal Pathogens and Disease
Volume 69
Issue number 2
Pages 101-113
Publication date
Full text links
Publisher website (DOI) 10.1111/2049-632x.12060
Europe PubMed Central 23821533
Pubmed 23821533
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