Computational fluid dynamics assisted characterization of parafoveal hemodynamics in normal and diabetic eyes using adaptive optics scanning laser ophthalmoscopy
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Yang Lu Miguel O Bernabeu Jan Lammer Charles C Cai Martin Jones Claudio A Franco Lloyd Paul Aiello Jennifer K SunAbstract
Diabetic retinopathy (DR) is the leading cause of visual loss in working-age adults worldwide. Previous studies have found hemodynamic changes in the diabetic eyes, which precede clinically evident pathological alterations of the retinal microvasculature. There is a pressing need for new methods to allow greater understanding of these early hemodynamic changes that occur in DR. In this study, we propose a noninvasive method for the assessment of hemodynamics around the fovea (a region of the eye of paramount importance for vision). The proposed methodology combines adaptive optics scanning laser ophthalmoscopy and computational fluid dynamics modeling. We compare results obtained with this technique with in vivo measurements of blood flow based on blood cell aggregation tracking. Our results suggest that parafoveal hemodynamics, such as capillary velocity, wall shear stress, and capillary perfusion pressure can be noninvasively and reliably characterized with this method in both healthy and diabetic retinopathy patients.
Journal details
Journal Biomedical Optics Express
Volume 7
Issue number 12
Pages 4958-4973
Available online
Publication date
Full text links
Publisher website (DOI) 10.1364/boe.7.004958
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Europe PubMed Central 28078170
Pubmed 28078170