Computational methods for analysis of tumor clonality and evolutionary history

Journal Article: Methods in Molecular BiologyYear Published: (2019) Volume Number: 1878, Article Number: 217-226

Authors

Goh, Gerald; McGranahan, Nicholas; Wilson, Gareth A.

Cancer is an evolutionary process. Recent advances in sequencing technologies have allowed us to investigate intratumor heterogeneity at the single nucleotide level. Here, we describe computational methods that use sequencing data to identify genetically distinct tumor subclones and reconstruct tumor evolutionary histories.