Consensus on precision medicine for metastatic cancers: a report from the MAP conference
Authors list
Charles Swanton J-C Soria A Bardelli A Biankin C Caldas S Chandarlapaty L de Koning C Dive J Feunteun S-Y Leung R Marais ER Mardis N McGranahan G Middleton SA Quezada J Rodón N Rosenfeld C Sotiriou F AndréAbstract
Recent advances in biotechnologies have led to the development of multiplex genomic and proteomic analyses for clinical use. Nevertheless, guidelines are currently lacking to determine which molecular assays should be implemented in metastatic cancers. The first MAP conference was dedicated to exploring the use of genomics to better select therapies in the treatment of metastatic cancers. Sixteen consensus items were covered. There was a consensus that new technologies like next-generation sequencing of tumors and ddPCR on circulating free DNA have convincing analytical validity. Further work needs to be undertaken to establish the clinical utility of liquid biopsies and the added clinical value of expanding from individual gene tests into large gene panels. Experts agreed that standardized bioinformatics methods for biological interpretation of genomic data are needed and that precision medicine trials should be stratified based on the level of evidence available for the genomic alterations identified.
Journal details
Journal Annals of Oncology
Volume 27
Issue number 8
Pages 1443-1448
Publication date
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Publisher website (DOI) 10.1093/annonc/mdw192
Europe PubMed Central 27143638
Pubmed 27143638
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