Cortical neurogenesis requires Bcl6-mediated transcriptional repression of multiple self-renewal-promoting extrinsic pathways
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Jerome Bonnefont Luca Tiberi Jelle van den Ameele Delphine Potier Zachary Gaber Xionghui Lin Angéline Bilheu Adèle Herpoel Fausto D Velez Bravo Francois Guillemot Stein Aerts Pierre VanderhaeghenAbstract
During neurogenesis, progenitors switch from self-renewal to differentiation through the interplay of intrinsic and extrinsic cues, but how these are integrated remains poorly understood. Here, we combine whole-genome transcriptional and epigenetic analyses with in vivo functional studies to demonstrate that Bcl6, a transcriptional repressor previously reported to promote cortical neurogenesis, acts as a driver of the neurogenic transition through direct silencing of a selective repertoire of genes belonging to multiple extrinsic pathways promoting self-renewal, most strikingly the Wnt pathway. At the molecular level, Bcl6 represses its targets through Sirt1 recruitment followed by histone deacetylation. Our data identify a molecular logic by which a single cell-intrinsic factor represses multiple extrinsic pathways that favor self-renewal, thereby ensuring robustness of neuronal fate transition.
Journal details
Journal Neuron
Volume 103
Issue number 6
Pages 1096-1108.e4
Available online
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Publisher website (DOI) 10.1016/j.neuron.2019.06.027
Figshare View on figshare
Europe PubMed Central 31353074
Pubmed 31353074
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