Corticosteroid therapy, vitamin D status, and inflammatory cytokine profile in the HIV-TB immune reconstitution inflammatory syndrome (TB-IRIS)

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Authors list

Anali Conesa-Botella Graeme Meintjes Anna K Coussens Helen van der Plas Rene Goliath Charlotte Schutz Rodrigo Moreno-Reyes Meera Mehta Adrian R Martineau Robert Wilkinson Robert Colebunders Katalin Wilkinson
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Abstract

Tuberculosis-immune reconstitution inflammatory syndrome (TB-IRIS) in patients coinfected with human immunodeficiency virus (HIV) and tuberculosis starting antiretroviral therapy (ART) is associated with hypercytokinemia. As adjunctive corticosteroid therapy and vitamin D have immunomodulatory properties, we investigated the relationship between cytokine/chemokine profiles, corticosteroid use, and vitamin D deficiency in TB-IRIS patients.

Journal details

Journal Clinical Infectious Diseases
Volume 55
Issue number 7
Pages 1004-1011
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Full text links

Publisher website (DOI) 10.1093/cid/cis577
Europe PubMed Central 22715179
Pubmed 22715179

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