deconstructSigs: delineating mutational processes in single tumors distinguishes DNA repair deficiencies and patterns of carcinoma evolutionMore about Open Access at the Crick
Authors listRachel Rosenthal Nicholas McGranahan Javier Herrero Barry S Taylor Charles Swanton
Analysis of somatic mutations provides insight into the mutational processes that have shaped the cancer genome, but such analysis currently requires large cohorts. We develop deconstructSigs, which allows the identification of mutational signatures within a single tumor sample.
Journal Genome Biology
Issue number 1